Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health.
Pei-Chien TsaiCraig A GlastonburyMelissa N EliotSailalitha BollepalliIdil YetJuan E Castillo-FernandezElena Carnero-MontoroThomas HardimanTiphaine C MartinAlice VickersMassimo ManginoKirsten WardKirsi H PietiläinenPanos DeloukasTim D SpectorAna ViñuelaEric B LoucksMiina OllikainenKarl T KelseyKerrin S SmallJordana T BellPublished in: Clinical epigenetics (2018)
Our results provide the first comprehensive characterization of coordinated DNA methylation and gene expression markers of smoking in adipose tissue. The findings relate to human metabolic health and give insights into understanding the widespread health consequence of smoking outside of the lung.