Are In Vitro Human Blood-Brain-Tumor-Barriers Suitable Replacements for In Vivo Models of Brain Permeability for Novel Therapeutics?

Archana Prashanth Heather DonaghyShihani P StonerAmanda L HudsonHelen R WheelerConnie I Diakos Viive M HowellGeorges E GrauKelly J McKelvey

Published in: Cancers (2021)

In vitro co-culture BBB models utilizing stem cell-derived or primary cells are a suitable proxy for brain permeability studies in order to reduce animal use in medical research.

Keyphrases

endothelial cells
resting state
white matter
induced apoptosis
functional connectivity
healthcare
blood brain barrier
cerebral ischemia
cell cycle arrest
small molecule
endoplasmic reticulum stress
induced pluripotent stem cells
multiple sclerosis