Mass Production of Rg1-Loaded Small Extracellular Vesicles Using a 3D Bioreactor System for Enhanced Cardioprotective Efficacy of Doxorubicin-Induced Cardiotoxicity.

Yunfeng DiShuang ZhaoHuilan FanWei LiGuangjian JiangYong WangChun LiWei WangJingyu Wang

Published in: Pharmaceutics (2024)

The 3D culture system scaled up the production of sEVs, which facilitated the Rg1 delivery and attenuated cardiomyocyte apoptosis, suggesting a potential treatment of DOX-induced cardiotoxicity.

Keyphrases

high glucose
diabetic rats
drug delivery
oxidative stress
endothelial cells
cancer therapy
drug induced
endoplasmic reticulum stress
cell death
angiotensin ii
wastewater treatment
cell cycle arrest
cell proliferation
risk assessment
climate change