Variations of interleukin-1 receptor-associated kinase-4 encoding gene were not associated with post-bronchiolitis lung function.
Riikka RiikonenEero LauhkonenJohanna TeräsjärviSari TörmänenKirsi NuolivirtaQiushui HeMatti KorppiPublished in: Acta paediatrica (Oslo, Norway : 1992) (2020)
Interleukin-1 receptor associated kinase-4 (IRAK4) encoded by the IRAK4 gene mediates signals of innate immunity. Single nucleotide polymorphisms (SNP) of the IRAK4 rs4251513 and rs4251520 were associated with an increased risk of early transient wheezing, when 94 SNPs were studied in 2007 Dutch and 7242 French children prospectively followed-up for eight years from birth (1).
Keyphrases
- lung function
- genome wide
- copy number
- cystic fibrosis
- chronic obstructive pulmonary disease
- dna methylation
- air pollution
- protein kinase
- tyrosine kinase
- genome wide identification
- gene expression
- binding protein
- cerebral ischemia
- blood brain barrier
- high density
- transcription factor
- subarachnoid hemorrhage
- genome wide association
- pregnancy outcomes