Impact of Therapeutic Interventions on Cerebral Autoregulatory Function Following Severe Traumatic Brain Injury: A Secondary Analysis of the BOOST-II Study.
Ayush PrasadEmily J GilmoreJennifer A KimLiza BegunovaMadelynne OlexaRachel BeekmanGuido J FalconeCharles MatoukSantiago Ortega-GutierrezNancy R TemkinJason BarberRamon Diaz-ArrastiaAdam de HavenonNils H PetersenPublished in: Neurocritical care (2023)
Our analysis suggests that brain tissue hypoxia is associated with cerebral hypoperfusion characterized by increased time with CPP below the lower limit of autoregulation. Interventions to increase CPP appear to improve autoregulation. Further studies are needed to validate the importance of autoregulation as a modifiable variable with the potential to improve outcomes.
Keyphrases
- severe traumatic brain injury
- cerebral blood flow
- subarachnoid hemorrhage
- physical activity
- cerebral ischemia
- traumatic brain injury
- white matter
- endothelial cells
- type diabetes
- resting state
- skeletal muscle
- metabolic syndrome
- case control
- adipose tissue
- blood brain barrier
- human health
- multiple sclerosis
- weight loss
- insulin resistance