Deep brain stimulation reduces evoked potentials with a dual time course in freely moving rats: Potential neurophysiological basis for intermittent as an alternative to continuous stimulation.
Mathieu SprengersRobrecht RaedtLars Emil LarsenJean DelbekeWytse Jan WadmanPaul BoonKristl VonckPublished in: Epilepsia (2020)
Deep brain stimulation induced both acute temporary effects compatible with axonal block and/or synaptic depression, and longer-lasting potentially cumulative EP reductions, suggesting the involvement of homeostatic plasticity or long-term depression. This dual time course may parallel the different temporal patterns of improvement observed in clinical trials. The longer-lasting reductions provide a potential neurophysiological basis for the use of intermittent DBS-as typically used in epilepsy patients-as an alternative to continuous DBS.
Keyphrases
- deep brain stimulation
- parkinson disease
- obsessive compulsive disorder
- clinical trial
- end stage renal disease
- depressive symptoms
- chronic kidney disease
- ejection fraction
- newly diagnosed
- high intensity
- drug induced
- liver failure
- sleep quality
- peritoneal dialysis
- prognostic factors
- high glucose
- respiratory failure
- patient reported outcomes
- intensive care unit
- risk assessment
- phase ii
- acute respiratory distress syndrome
- endothelial cells
- patient reported
- open label
- optical coherence tomography
- optic nerve