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Frequent FGFR1 hotspot alterations in driver-unknown low-grade glioma and mixed neuronal-glial tumors.

Sophie EngelhardtFelix BehlingRudi BeschornerFranziska EckertPatricia KohlhofMarcos TatagibaGhazaleh TabatabaiMartin U SchuhmannMartin EbingerCornelia Brendle
Published in: Journal of cancer research and clinical oncology (2022)
FGFR1 hotspot mutations are the fifth most prevailing alteration in LGG/MNGT. Performing FGFR1 sequencing analysis in driver-unknown low-grade brain tumors could yield up to 12% FGFR1 N546/K656 mutant cases.
Keyphrases
  • low grade
  • high grade
  • single cell
  • spinal cord injury
  • cerebral ischemia