Frequent FGFR1 hotspot alterations in driver-unknown low-grade glioma and mixed neuronal-glial tumors.
Sophie EngelhardtFelix BehlingRudi BeschornerFranziska EckertPatricia KohlhofMarcos TatagibaGhazaleh TabatabaiMartin U SchuhmannMartin EbingerCornelia BrendlePublished in: Journal of cancer research and clinical oncology (2022)
FGFR1 hotspot mutations are the fifth most prevailing alteration in LGG/MNGT. Performing FGFR1 sequencing analysis in driver-unknown low-grade brain tumors could yield up to 12% FGFR1 N546/K656 mutant cases.