Frequent FGFR1 hotspot alterations in driver-unknown low-grade glioma and mixed neuronal-glial tumors.

Sophie EngelhardtFelix BehlingRudi BeschornerFranziska EckertPatricia KohlhofMarcos TatagibaGhazaleh TabatabaiMartin U SchuhmannMartin EbingerCornelia Brendle

Published in: Journal of cancer research and clinical oncology (2022)

FGFR1 hotspot mutations are the fifth most prevailing alteration in LGG/MNGT. Performing FGFR1 sequencing analysis in driver-unknown low-grade brain tumors could yield up to 12% FGFR1 N546/K656 mutant cases.

Keyphrases

low grade
high grade
single cell
spinal cord injury
cerebral ischemia