Electronic Health Record Based Algorithm to Identify Patients with Autism Spectrum Disorder.

Todd LingrenPei ChenJoseph BochenekFinale Doshi-VelezPatty Manning-CourtneyJulie BickelLeah Wildenger WelchonsJudy ReinholdNicole BingYizhao NiWilliam BarbaresiFrank MentchMelissa BasfordJoshua DennyLyam VazquezCassandra PerryBahram NamjouHaijun QiuJohn ConnollyDebra AbramsIngrid A HolmBeth A CobbNataline LingrenImre SoltiHakon HakonarsonIsaac S KohaneJohn HarleyGuergana Savova

Published in: PloS one (2016)

In a large cross-institutional cohort, co-occurrence patterns of comorbidities in ASDs provide further hypothetical evidence for distinct courses in ASD. The proposed automated algorithms for cohort selection open avenues for other large-scale EHR studies and individualized treatment of ASD.

Keyphrases

autism spectrum disorder
electronic health record
machine learning
deep learning
attention deficit hyperactivity disorder
intellectual disability
clinical decision support
adverse drug
high throughput
minimally invasive
combination therapy
case control
replacement therapy