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A systematic review on the genotoxic effect of serotonin and norepinephrine reuptake inhibitors (SNRIs) antidepressants.

Mahnaz AhmadimaneshSoudabeh BalarastaghiMarzieh RashediniaRezvan Yazdian-Robati
Published in: Psychopharmacology (2020)
The database searches retrieved 336 records, 18 of which met the inclusion criteria. Evaluation of the selected articles showed that a total of 9 articles were appropriate for final review. Most of these studies (78%) reported positive results for the genotoxicity of SNRIs CONCLUSION: Finally, we can conclude that these drugs have the potential to damage DNA.
Keyphrases
  • circulating tumor
  • major depressive disorder
  • cell free
  • oxidative stress
  • single molecule
  • tyrosine kinase
  • case control
  • human health
  • risk assessment
  • circulating tumor cells