Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells.
Kazushige YoshidaMasanori OkamotoJun SasakiChika KurodaHaruka IshidaKatsuya UedaHirokazu IdetaTakayuki KamanakaAtsushi SobajimaTakashi TakizawaManabu TanakaKaoru AokiTakeshi UemuraHiroyuki KatoHisao HaniuNaoto SaitoPublished in: BMC cancer (2020)
Here we clarify for the first time an additional mechanism of anti-tumour effect-as exerted by anti-PD-1 antibody decreasing Treg- we anticipate that our findings will lead to the development of new methods for cancer treatment.