Overexpression of miR-181a regulates the Warburg effect in triple-negative breast cancer.

Y WangH TahiriChun YangM GuXiangyan RuanP Hardy

Published in: Climacteric : the journal of the International Menopause Society (2022)

Our results demonstrate that miR-181a may regulate glycolysis in MDA-MB-231 TNBC cells, potentially via interference with components of the AKT3-HIF-1α and PGRMC1 pathways. These results suggest that miR-181a might be developed as a therapeutic agent for use in antineoplastic regimens directed at TNBC and PGRMC1-overexpressing breast cancers.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
cell cycle arrest
induced apoptosis
signaling pathway
cell death