Skeletal muscle mTORC1 regulates neuromuscular junction stability.
Martina BaraldoAlessia GeremiaMarco PirazziniLeonardo NogaraFrancesca SolagnaClara TürkHendrik NolteVanina RomanelloAram MegighianSimona BoncompagniMarcus KrugerMarco SandriBert BlaauwPublished in: Journal of cachexia, sarcopenia and muscle (2019)
Our study shows that mTOR signalling in skeletal muscle fibres is critical for maintaining proper fibre innervation, preserving the NMJ structure in both the muscle fibre and the motor neuron. In addition, considering the beneficial effects of exercise in most pathologies affecting the NMJ, our findings suggest that part of these beneficial effects of exercise are through the well-established activation of mTORC1 in skeletal muscle during and after exercise.