FSTL1 aggravates OVA-induced inflammatory responses by activating the NLRP3/IL-1β signaling pathway in mice and macrophages.
Yan WangDong ZhangTian LiuJun-Fei WangJin-Xiang WuJi-Ping ZhaoJia-Wei XuJin-Tao ZhangLiang DongPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2021)
The study results showed that FSTL1 played an important role in allergic airway inflammation by activating NLRP3/IL-1β. Hence, inhibition FSTL1 could be applied as a therapeutic agent against asthma.
Keyphrases
- signaling pathway
- pi k akt
- chronic obstructive pulmonary disease
- epithelial mesenchymal transition
- allergic rhinitis
- induced apoptosis
- high glucose
- diabetic rats
- lung function
- type diabetes
- high fat diet induced
- drug induced
- metabolic syndrome
- skeletal muscle
- adipose tissue
- insulin resistance
- endothelial cells
- atopic dermatitis