Myelin endocytosis by brain endothelial cells causes endothelial iron overload and oligodendroglial iron hunger in hypoperfusion-induced white matter injury.
Yuxin LiuXinmei KangJiahao LinYixin LiuSanxin LiuChunyi LiXiaohui DengHuipeng HuangTiemei LiShisi WangDanli LuYuxuan JiangZhengqi LuWei CaiTingting LuPublished in: CNS neuroscience & therapeutics (2024)
The iron imbalance between BVECs and oligodendroglial lineage cells is a potential therapeutic target in hypoperfusion-induced white matter injury.
Keyphrases
- white matter
- high glucose
- endothelial cells
- multiple sclerosis
- diabetic rats
- induced apoptosis
- cognitive impairment
- iron deficiency
- cell cycle arrest
- drug induced
- oxidative stress
- single cell
- cell death
- cell proliferation
- endoplasmic reticulum stress
- signaling pathway
- vascular endothelial growth factor
- resting state