Augmented Reduced-Intensity Regimen Does Not Improve Postallogeneic Transplant Outcomes in Acute Myeloid Leukemia.
Charles F CraddockAimee JacksonJustin LokeShamyla SiddiqueAndrea HodgkinsonJohn MasonGeorgia AndrewSandeep NagraRam MalladiAndrew PeniketMaria H GilleeceRahuman SalimEleni TholouliVictoria PotterCharles CrawleyKeith WheatleyRachel ProtheroeParesh VyasAnn HunterAnne ParkerKeith WilsonJiří PavlůJennifer L ByrneRichard DilonNaeem KhanSylvie D FreemanSylvie D FreemanPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2020)
The intensified RIC conditioning regimen, FLAMSA-Bu, did not improve outcomes in adults transplanted for high-risk AML or MDS regardless of pretransplant MRD status. Our data instead support the exploration of interventions with the ability to accelerate acquisition of full donor T-cell chimerism as a tractable strategy to improve outcomes in patients allografted for AML.