Hepatic C-X-C chemokine receptor type 6-expressing innate lymphocytes limit detrimental myeloid hyperactivation in acute liver injury.

Felix Heymann Jana C Mossanen Moritz PeiselerPatricia M NiemietzBruna Araujo David Oliver Krenkel Anke Liepelt Matheus Batista Carneiro Marlene S Kohlhepp Paul Kubes Frank Tacke

Published in: Hepatology communications (2023)

Our study identifies a crucial role of CXCR6-expressing liver innate lymphocytes as orchestrators in acute liver injury containing IL-17-mediated myeloid cell infiltration. Hence, strengthening the CXCR6-axis or downstream inhibition of IL-17 could yield novel therapeutics in ALF.

Keyphrases

liver injury
drug induced
immune response
dendritic cells
peripheral blood
bone marrow
acute myeloid leukemia
liver failure
single cell
respiratory failure
genome wide
small molecule
cell therapy
intensive care unit
gene expression
hepatitis b virus
wild type
binding protein
mechanical ventilation