Androgen promotes squamous differentiation of atypical cells in cervical intraepithelial neoplasia via an ELF3-dependent pathway.

Takeo MatsumotoTakuma SuzukiMitsuhiro NakamuraMegumi YamamotoTakashi IizukaMasanori OnoKyosuke KagamiHaruki KasamaTatsuhito KandaYuya SakaiJunpei IwadareAyumi MatsuokaKayo KayahashiKousho WakaeMasamichi MuramatsuSatoru KyoYasuhiko YamamotoYasunari MizumotoTakiko DaikokuHiroshi Fujiwara

Published in: Cancer medicine (2023)

Androgen is a novel factor that regulates squamous differentiation in the early stage of CIN, providing a new strategy for nonsurgical and hormone-induced differentiation therapy against CIN1 and CIN2.

Keyphrases

high grade
early stage
low grade
induced apoptosis
high glucose
stem cells
signaling pathway
lymph node
pi k akt