Cadmium-induced neurodegeneration and activation of noncanonical sonic hedgehog pathway in rat cerebellum.

Mubeena Mariyath P MMehdi Hayat ShahiMohd TayyabShirin FarheenNabeela KhanamSartaj TabassumAsif Ali

Published in: Journal of biochemical and molecular toxicology (2018)

A disturbed oxidative balance, DNA damage, and an upregulated Shh signaling pathway were observed in cadmium-treated samples. Loss of structural integrity in cerebellum and loss of motor activity were observed in cadmium-treated rats.

Keyphrases

dna damage
signaling pathway
heavy metals
oxidative stress
diabetic rats
high glucose
pi k akt
dna repair
epithelial mesenchymal transition
drug induced
risk assessment
cell proliferation
stress induced