Prangos ferulacea (L.) ameliorates behavioral alterations, hippocampal oxidative stress markers, and apoptotic deficits in a rat model of autism induced by valproic acid.

Maryam SaadatAbbas Ali TaherianMohammad Reza AldaghiPayman Raise-AbdullahiHamid Reza SameniAbbas Ali Vafaei

Published in: Brain and behavior (2023)

The findings of this study suggest that postnatal administration of PF can prevent VPA-induced ASD-like behaviors by exhibiting antiapoptotic and antioxidant properties. Therefore, PF may have the potential as an adjunct in the management of ASD.

Keyphrases

autism spectrum disorder
oxidative stress
diabetic rats
intellectual disability
attention deficit hyperactivity disorder
anti inflammatory
cell death
traumatic brain injury
high glucose
preterm infants
mouse model
climate change
working memory
human health