Impact of diabetes on promoting the growth of breast cancer.

Ping-Chieh ChouHyun Ho ChoiYizhi HuangEnrique Fuentes-MatteiGuermarie Velazquez-TorresFanmao ZhangLiem PhanJaehyuk LeeYanxia ShiJames A BanksonYun WuHuamin WangRuiying ZhaoSai-Ching Jim YeungMong-Hong Lee

Published in: Cancer communications (London, England) (2021)

MMTV-ErbB2/Leprdb/db mouse model was able to recapitulate diabetic HER2+ human breast cancer. Additionally, our results defined the signaling pathways deregulated in HER2+ breast cancer under diabetic condition, which can be intervened by anti-insulin resistance therapy.

Keyphrases

type diabetes
insulin resistance
mouse model
endothelial cells

signaling pathway
cardiovascular disease
wound healing

metabolic syndrome
high fat diet
skeletal muscle

glycemic control
tyrosine kinase
oxidative stress