Impact of diabetes on promoting the growth of breast cancer.
Ping-Chieh ChouHyun Ho ChoiYizhi HuangEnrique Fuentes-MatteiGuermarie Velazquez-TorresFanmao ZhangLiem PhanJaehyuk LeeYanxia ShiJames A BanksonYun WuHuamin WangRuiying ZhaoSai-Ching Jim YeungMong-Hong LeePublished in: Cancer communications (London, England) (2021)
MMTV-ErbB2/Leprdb/db mouse model was able to recapitulate diabetic HER2+ human breast cancer. Additionally, our results defined the signaling pathways deregulated in HER2+ breast cancer under diabetic condition, which can be intervened by anti-insulin resistance therapy.