Dysfunctional epigenetic aging of the normal colon and colorectal cancer risk.

Ting WangSean K MadenGeorg E LuebeckChristopher I LiPolly A NewcombCornelia M UlrichJi-Hoon E JooDaniel D BuchananRoger L MilneMelissa C SoutheyKelly T CarterAmber R WillbanksYanxin LuoMing YuWilliam M Grady

Published in: Clinical epigenetics (2020)

Among the four DNA methylation-based measures of biological age, the Horvath clock is the most accurate for estimating the chronological age of individuals. Individuals with a high risk for CRC have epigenetic age deceleration in their normal colons measured by the PhenoAge clock, which may reflect a dysfunctional epigenetic aging process.

Keyphrases

dna methylation
gene expression
genome wide
high resolution
copy number