HLA-DR-Expressing Fibroblast-Like Synoviocytes Are Inducible Antigen Presenting Cells That Present Autoantigens in Lyme Arthritis.

Joseph R RouseRebecca DannerAmanda WahhabMichaela PereckasChristine NguyenMecaila E McClune Allen C SteereKlemen StrleBrandon L JutrasRobert B Lochhead

Published in: ACR open rheumatology (2024)

MHC-II+ FLS are inducible APCs that can induce CD4+ T cell activation in an antigen- and CD40-dependent manner. Activated FLS can also present ECM-derived Lyme autoantigens, implicating FLS in amplifying tissue-localized autoimmunity in LA.

Keyphrases

induced apoptosis
cell cycle arrest
rheumatoid arthritis
case report
endoplasmic reticulum stress
oxidative stress
cell death
signaling pathway
cell proliferation
pi k akt
wound healing