Lung-Adapted Staphylococcus aureus Isolates With Dysfunctional Agr System Trigger a Proinflammatory Response.

Elodie RamondAgathe LepissierXiongqi DingClémence BouvierXin TanDaniel EuphrasiePierre MonbernardMarion DupuisBruno SaubaméaIvan NemazanyyXavier NassifAgnès FerroniIsabelle Sermet-GaudelusAlain CharbitMathieu Coureuil Anne Jamet

Published in: The Journal of infectious diseases (2022)

Our results suggest an unexpected direct role of bacterial lung adaptation in the progression of chronic lung disease by promoting a proinflammatory response through acquired agr dysfunction.

Keyphrases

staphylococcus aureus
oxidative stress
escherichia coli
biofilm formation
cystic fibrosis
drug induced