αvβ3 Integrin Expression and Mitogenic Effects by Thyroid Hormones in Chronic Lymphocytic Leukemia.

Uri AbadiAvivit WeiszDvora KidronAviva KatzavAleck HercbergsPaul J DavisMartin H EllisOsnat Ashur-Fabian

Published in: Journal of clinical medicine (2021)

αvβ3 integrin is expressed on primary CLL cells and is induced by thyroid hormones. We further suggest that the hormones are mitogenic in these cells, presumably via αvβ3-mediated signaling.

Keyphrases

chronic lymphocytic leukemia
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
signaling pathway
cell death
cell migration
long non coding rna
cell adhesion
binding protein