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Preliminary Experience of Liquid Biopsy in Lung Cancer Compared to Conventional Assessment: Light and Shadows.

Marco MontellaGiovanni CianiVincenza GranataRoberta FuscoFrancesca GrassiAndrea RonchiImmacolata CozzolinoRenato FrancoFederica Zito MarinoFabrizio UrraroRiccardo MontiRoberto SiricaGiovanni SavareseUgo ChianeseAngela NebbiosoLucia AltucciMaria Teresa VietriValerio NardoneAlfonso ReginelliRoberta Grassi
Published in: Journal of personalized medicine (2022)
We showed that, when a genetic mutation was detected in pathological examination, this was always detected by liquid biopsy, demonstrating a very high concordance rate of genomic testing between tissues and their corresponding mutations obtained by liquid biopsy, without cases of false-negative results. In addition, in our study, liquid biopsy highlighted 26 mutations, with the prevalence of ALK mutation in 96.6% of patients, supporting the idea that this approach could be an effective tool in cases with insufficient tumor tissue specimens or in cases where tissue specimens are not obtainable.
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