SIRT3 activator honokiol ameliorates surgery/anesthesia-induced cognitive decline in mice through anti-oxidative stress and anti-inflammatory in hippocampus.
Ji-Shi YeLei ChenYa-Yuan LuShao-Qing LeiMian PengZhong-Yuan XiaPublished in: CNS neuroscience & therapeutics (2018)
These results suggested that activation of SIRT3 by honokiol may attenuate surgery/anesthesia-induced cognitive impairment in mice through regulation of oxidative stress and neuroinflammatory in hippocampus.
Keyphrases
- oxidative stress
- diabetic rats
- cognitive decline
- cognitive impairment
- minimally invasive
- ischemia reperfusion injury
- high glucose
- coronary artery bypass
- mild cognitive impairment
- anti inflammatory
- dna damage
- high fat diet induced
- induced apoptosis
- drug induced
- endothelial cells
- surgical site infection
- type diabetes
- mouse model
- metabolic syndrome
- coronary artery disease
- adipose tissue
- endoplasmic reticulum stress
- heat shock