Insights into disseminated MS brain pathology with multimodal diffusion tensor and PET imaging.
Svetlana BezukladovaJouni TuiskuMarkus MatilainenAnna VuorimaaMarjo NylundSarah SmithMarcus SucksdorffMehrbod MohammadianVirva SaunavaaraSini LaaksonenJohanna RokkaJuha O RinneEero RissanenLaura M AirasPublished in: Neurology(R) neuroimmunology & neuroinflammation (2020)
Widespread structural disruption in the NAWM is linked to neuroinflammation, and both phenomena associate with clinical disability. Multimodal PET and DTI allow in vivo evaluation of widespread MS pathology not visible using cMRI.
Keyphrases
- pet imaging
- multiple sclerosis
- white matter
- mass spectrometry
- ms ms
- pain management
- positron emission tomography
- cerebral ischemia
- traumatic brain injury
- resting state
- computed tomography
- lipopolysaccharide induced
- lps induced
- cognitive impairment
- functional connectivity
- brain injury
- subarachnoid hemorrhage
- chronic pain
- blood brain barrier