The 5-HT7 receptor antagonist SB 269970 ameliorates corticosterone-induced alterations in 5-HT7 receptor-mediated modulation of GABAergic transmission in the rat dorsal raphe nucleus.

Joanna SowaMagdalena KusekMarcin SiwiecJoanna Ewa SowaBartosz BobulaKrzysztof TokarskiGrzegorz Hess

Published in: Psychopharmacology (2018)

Elevated corticosterone level reduces DRN 5HT7 receptor reactivity and decreases GABAergic transmission within the DRN, which can be reversed by the 5-HT7 receptor antagonist SB 269970.

Keyphrases

spinal cord
oxidative stress
high glucose
diabetic rats
mouse model
spinal cord injury
endothelial cells
binding protein