Functional network analysis reveals potential repurposing of β-blocker atenolol for pancreatic cancer therapy.

Adam Hermawan Herwandhani Putri Rohmad Yudi Utomo

Published in: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences (2020)

In conclusion, atenolol can potentially be repurposed to target pancreatic cancer cells by modulating MMP9 and NF-κB signaling. The results of this study need to be further validated in vitro and in vivo.

Keyphrases

network analysis
cancer therapy
signaling pathway
drug delivery
oxidative stress
pi k akt
risk assessment
human health