Chikungunya virus vaccine candidate incorporating synergistic mutations is attenuated and protects against virulent virus challenge.

Anthony J LentscherNicole McAllisterKira A GriswoldJames L MartinOlivia L WelshDanica M SutherlandLaurie A SilvaTerence S Dermody

Published in: The Journal of infectious diseases (2022)

These data suggest that restriction of LAV replication in skeletal muscle enhances tolerability of reactogenic vaccine candidates and may improve the rational design of CHIKV vaccines.

Keyphrases

skeletal muscle
disease virus
zika virus
insulin resistance
open label
electronic health record
big data
dengue virus
clinical trial
type diabetes
aedes aegypti
metabolic syndrome
machine learning
adipose tissue
drug delivery
double blind
artificial intelligence
deep learning