In vitro activity of cefiderocol against a global collection of carbapenem-resistant Pseudomonas aeruginosa with a high level of carbapenemase diversity.
Christian M GillDebora SantiniDavid P Nicolaunull nullPublished in: The Journal of antimicrobial chemotherapy (2024)
Cefiderocol displayed potent in vitro activity in this global cohort of carbapenem-resistant P. aeruginosa including >200 carbapenemase-harbouring isolates. Cefiderocol was highly active against MBL-producing isolates, where treatment options are limited. These data can help guide empirical therapy guidelines based on local prevalence of carbapenemase-producing P. aeruginosa or in response to rapid molecular diagnostics.
Keyphrases
- gram negative
- multidrug resistant
- acinetobacter baumannii
- pseudomonas aeruginosa
- klebsiella pneumoniae
- drug resistant
- genetic diversity
- risk factors
- electronic health record
- clinical practice
- biofilm formation
- escherichia coli
- mesenchymal stem cells
- single molecule
- machine learning
- cell therapy
- loop mediated isothermal amplification