Anthropometric measures and serum estrogen metabolism in postmenopausal women: the Women's Health Initiative Observational Study.
Hannah OhSally B CoburnCharles E MatthewsRoni T FalkErin S LeBlancJean Wactawski-WendeJoshua SampsonRuth M PfeifferLouise A BrintonNicolas WentzensenGarnet L AndersonJoAnn E MansonChu ChenOleg ZaslavskyXia XuBritton TrabertPublished in: Breast cancer research : BCR (2017)
Our data suggest that postmenopausal BMI is associated with increased circulating levels of parent estrogens and reduced methylation of catechol estrogen metabolites, the estrogen metabolism patterns that have previously been associated with higher breast cancer risk.
Keyphrases
- breast cancer risk
- postmenopausal women
- bone mineral density
- estrogen receptor
- public health
- body composition
- healthcare
- body mass index
- ms ms
- mental health
- electronic health record
- quality improvement
- health information
- polycystic ovary syndrome
- dna methylation
- gene expression
- risk assessment
- weight gain
- physical activity
- type diabetes
- genome wide
- big data
- insulin resistance
- pregnancy outcomes
- machine learning
- weight loss
- climate change
- metabolic syndrome