Pre-implantation alcohol exposure induces lasting sex-specific DNA methylation programming errors in the developing forebrain.

L M LegaultK DoironM Breton-LarrivéeA Langford-AvelarA LemieuxM CaronL A Jerome-MajewskaD SinnettSerge McGraw

Published in: Clinical epigenetics (2021)

These findings support that alcohol-induced DNA methylation programming deviations during pre-implantation could contribute to the manifestation of neurodevelopmental phenotypes associated with FASD.

Keyphrases

dna methylation
genome wide
gene expression
alcohol consumption
high glucose
diabetic rats
patient safety
drug induced
copy number
emergency department
adverse drug
oxidative stress
endothelial cells
spectrum disorder