Immunosuppressive Treg cells acquire the phenotype of effector-T cells in chronic lymphocytic leukemia patients.

Serena De MatteisChiara MolinariGiulia AbbatiTania RossiRoberta NapolitanoMartina GhettiAndrea Ghelli Luserna Di RoràGerardo MusuracaAlessandro LucchesiGian Matteo RigolinAntonio CuneoDaniele CalistriPier Paolo FattoriMassimiliano BonafèGiovanni Martinelli

Published in: Journal of translational medicine (2018)

Our data show that Tregs switch towards an effector-like phenotype in CLL patients. This multifaceted behavior is accompanied by an altered cytokine profiling and transcriptional program of immune genes, leading to a dysfunction in immune response in the peripheral blood environment of CLL patients.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
immune response
newly diagnosed
chronic lymphocytic leukemia
peripheral blood
oxidative stress
gene expression
induced apoptosis
cell death
inflammatory response
quality improvement
cell cycle arrest
heat stress
heat shock protein