Toll-like receptor 4 agonist and antagonist lipopolysaccharides modify innate immune response in rat brain circumventricular organs.
Alejandra Vargas-CaraveoAline SaydJavier Robledo-MontañaJavier R CasoJosé L M MadrigalBorja Garcia-BuenoJuan C LezaPublished in: Journal of neuroinflammation (2020)
In conclusion, at the doses tested, EC-LPS induces a stronger neuroinflammatory response than PG-LPS in CVOs, which might be related to their different potency as TLR4 agonists. The non-reduction of basal NF-κB activation and induction of rod microglia by RS-LPS, a cell morphology only present in severe brain injury and infections, suggests that this molecule must be carefully studied before being proposed as an anti-inflammatory treatment for neuroinflammation related to neurodegenerative/psychiatric diseases.
Keyphrases
- toll like receptor
- inflammatory response
- immune response
- lps induced
- brain injury
- anti inflammatory
- lipopolysaccharide induced
- nuclear factor
- subarachnoid hemorrhage
- cerebral ischemia
- traumatic brain injury
- single cell
- mental health
- signaling pathway
- dendritic cells
- drug induced
- stem cells
- combination therapy
- cognitive impairment
- spinal cord injury
- bone marrow
- spinal cord
- mesenchymal stem cells
- blood brain barrier
- cell proliferation