Systemic Administration of the Cyclin-Dependent Kinase Inhibitor (S)-CR8 Selectively Reduces Escalated Ethanol Intake in Dependent Rats.
Scott P GouldingGiordano de GuglielmoLieselot L G CarretteOlivier GeorgeCandice ContetPublished in: Alcoholism, clinical and experimental research (2019)
The selective effect of (S)-CR8 on excessive EtOH intake has potential therapeutic value for the treatment of alcohol use disorders. Our data do not support the hypothesis that this effect would be mediated by the inhibition of up-regulated CDK5 activity in the extended amygdala nor prefrontal cortex. However, increased activity of CDKs other than CDK5 in the BLA may contribute to excessive EtOH consumption in alcohol dependence. Other (S)-CR8 targets may also be implicated.
Keyphrases
- prefrontal cortex
- weight gain
- cell cycle
- body mass index
- functional connectivity
- electronic health record
- transcription factor
- big data
- cell proliferation
- combination therapy
- klebsiella pneumoniae
- escherichia coli
- artificial intelligence
- weight loss
- multidrug resistant
- resting state
- physical activity
- deep learning
- stress induced