The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma.
Lin YuanLeyuan WangXizi DuLing QinMing YangKai ZhouMengping WuYu YangZhiyuan ZhengYang XiangXiangping QuHuijun LiuXiaoqun QinChi LiuPublished in: Journal of translational medicine (2020)
The mRNA expression of FOXO3 and TP53 varies significantly in peripheral blood of LOA patients, which may be due to the regulation of DNA methylation. FOXO3 and TP53 methylation is a suitable blood biomarker to predict LOA, which may be useful targets for the risk diagnosis and clinical management of LOA.
Keyphrases
- dna methylation
- late onset
- peripheral blood
- genome wide
- transcription factor
- end stage renal disease
- gene expression
- pi k akt
- signaling pathway
- early onset
- ejection fraction
- chronic kidney disease
- newly diagnosed
- chronic obstructive pulmonary disease
- prognostic factors
- cell proliferation
- copy number
- cystic fibrosis
- patient reported outcomes