A magic kick for regeneration: role of mesenchymal stromal cell secretome in spermatogonial stem cell niche recovery.

Georgy SagaradzeNataliya BasalovaVladimir KirpatovskyDmitry OhobotovPeter NimiritskyOlga GrigorievaVladimir PopovArmais KamalovVsevolod TkachukAnastasia Yu Efimenko

Published in: Stem cell research & therapy (2019)

Our data suggest that MSCs mimic the functions of lost supportive cells within the stem cell niche, transiently providing paracrine stimuli for target cells and triggering tissue regenerative processes after damage.

Keyphrases

stem cells
induced apoptosis
cell therapy
cell cycle arrest
mesenchymal stem cells
bone marrow
oxidative stress
single cell
endoplasmic reticulum stress
cell death
electronic health record
cell proliferation
machine learning