GRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma.
Yuan LiYibo FanJinbang XuLongfei HuoAiling W ScottJiankang JinBoxuan YangShan ShaoLang MaYing WangXiaodan YaoMelissa Pool PizziMatheus Sewastjanow Da SilvaGuoliang ZhangLijuan ZhuoEun Jeong ChoKevin N DalbyNamita D ShanbhagZhenning WangWenliang LiShumei SongJaffer A AjaniPublished in: Journal of experimental & clinical cancer research : CR (2022)
GRK3, a poor prognosticator for survival, conferred aggressive phenotype. Genetic silencing of GRK3 or its inhibitor LD2 blunted GRK3-conferred malignant attributes, suggesting GRK3 as a novel therapeutic target in advanced GAC.