Response to Comment on "Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice".

Eduardo A Albornoz Richard Gordon Vinod Kumar Avril A B Robertson Kate Schroder Trent M Woodruff

Published in: Science translational medicine (2023)

We have replicated our original finding of elevated cleaved caspase-1 in mouse brains and neuroprotection by an NLRP3 inflammasome inhibitor in two mouse models of Parkinson's disease.

Keyphrases

nlrp inflammasome
mouse model
cell death
high fat diet induced
brain injury
induced apoptosis
type diabetes
oxidative stress
wild type
endoplasmic reticulum stress
metabolic syndrome