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Prediction of sustained fetal toxicity induced by ketoprofen based on PK/PD analysis using human placental perfusion and rat toxicity data.

Shingo TanakaTakeshi KanagawaKazuo MommaSatoko HoriHiroki SatohTakeshi NagamatsuTomoyuki FujiiTadashi KimuraYasufumi Sawada
Published in: British journal of clinical pharmacology (2017)
The present approach successfully described the sustained fetal toxicity after discontinuing the transdermal administration of ketoprofen.
Keyphrases
  • oxidative stress
  • endothelial cells
  • electronic health record
  • induced pluripotent stem cells
  • magnetic resonance imaging
  • artificial intelligence