Glutaminase inhibitor CB-839 increases radiation sensitivity of lung tumor cells and human lung tumor xenografts in mice.
Gunnar BoysenAzemat Jamshidi-ParsianMary A DavisEric Robb SiegelChristine M SimeckaRajshekhar A KoreRuud P M DingsRobert J GriffinPublished in: International journal of radiation biology (2019)
The results support the proposed mechanistic link between GLS activity and GSH synthesis and suggest that GLS inhibitors are effective radiosensitizers.