The significance of extensive HPV genotyping for cervical high-grade neoplasia among women with atypical glandular cells.

Xiao TangMegan L ZillaWei JiangYanmei HeDavid StarrLei LiLingling TongCheng WangWei WangKaixuan YangRutie YinChengquan Zhao

Published in: American journal of clinical pathology (2024)

In patients with an AGC Pap, the risk of having a cervical CIN3+ lesion is greatly increased by positivity for hrHPV types 16, 18, 58, 52, and/or 33. Incorporating comprehensive HPV genotyping into AGC cytology allows for refined risk stratification and more tailored management strategies.

Keyphrases

high grade
low grade
induced apoptosis
genome wide
high throughput
cell cycle arrest
genetic diversity
endoplasmic reticulum stress
oxidative stress
cell death
gene expression
dna methylation
ultrasound guided