Long wavelength-emissive Ru(II) metallacycle-based photosensitizer assisting in vivo bacterial diagnosis and antibacterial treatment.
Yuling XuChonglu LiXin MaWei TuoLe TuXiaopeng LiYan SunPeter J StangYao SunPublished in: Proceedings of the National Academy of Sciences of the United States of America (2022)
Ruthenium (Ru) complexes are developed as latent emissive photosensitizers for cancer and pathogen photodiagnosis and therapy. Nevertheless, most existing Ru complexes are limited as photosensitizers in terms of short excitation and emission wavelengths. Herein, we present an emissive Ru(II) metallacycle (herein referred to as 1) that is excited by 808-nm laser and emits at a wavelength of ∼1,000 nm via coordination-driven self-assembly. Metallacycle 1 exhibits good optical penetration (∼7 mm) and satisfactory reactive oxygen species production properties. Furthermore, 1 shows broad-spectrum antibacterial activity (including against drug-resistant Escherichia coli ) as well as low cytotoxicity to normal mammalian cells. In vivo studies reveal that 1 is employed in precise, second near-infrared biomedical window fluorescent imaging-guided, photo-triggered treatments in Staphylococcus aureus -infected mice models, with negligible side effects. This work thus broads the applications of supramolecular photosensitizers through the strategy of lengthening their wavelengths.
Keyphrases
- photodynamic therapy
- energy transfer
- drug resistant
- quantum dots
- fluorescence imaging
- staphylococcus aureus
- escherichia coli
- reactive oxygen species
- light emitting
- multidrug resistant
- high resolution
- acinetobacter baumannii
- high speed
- papillary thyroid
- biofilm formation
- stem cells
- type diabetes
- gene expression
- genome wide
- squamous cell
- bone marrow
- pseudomonas aeruginosa
- smoking cessation
- single cell
- dna methylation
- mass spectrometry
- young adults
- anti inflammatory
- replacement therapy