Wei-Tong-Xin exerts anti-inflammatory effects through TLR4-mediated macrophages M1/M2 polarization and affects GLP-1 secretion.

Xiaoying ZhangXihan YangShuanglin ZhangJinyu WangMengshi WangTiancheng MaMeiqi WanXinyan LvTingxu YanYing Jia

Published in: The Journal of pharmacy and pharmacology (2023)

Overall, WTX inhibited polarization of macrophages towards M1 phenotype but promoted the amounts of M2 phenotype, further the macrophages regulated by WTX alleviated GLP-1 content secreted by GLUTag cells. The aforementioned results were produced by WTX-mediated TLR4.

Keyphrases

toll like receptor
inflammatory response
immune response
induced apoptosis
nuclear factor
oxidative stress
cell death