The Role of Autoantibodies in Bone Metabolism and Bone Loss.
Barbara HauserUlrike SteffenPublished in: Calcified tissue international (2017)
Many autoimmune diseases are associated with deranged bone metabolism. The resulting localized or systemic bone loss can compromise the quality of life of patients by causing local bone deformities or fragility fractures. There is emerging evidence that antibodies have a direct impact on key players of bone homeostasis, in particular osteoclasts. Clinical and pre-clinical studies provide insight into the function of autoantibodies related to Rheumatoid Arthritis (rheumatoid factor, anti-citrullinated protein antibodies, and anti-carbamylated protein antibodies) and their inflammation-independent interaction with bone cells. Furthermore, we summarize the current knowledge about neutralizing antibodies to the antiresorptive protein osteoprotegerin, which have been described in patients with Coeliac Disease, Rheumatoid Arthritis, and Spondyloarthritis.
Keyphrases
- bone loss
- rheumatoid arthritis
- bone mineral density
- disease activity
- systemic lupus erythematosus
- end stage renal disease
- protein protein
- ankylosing spondylitis
- binding protein
- newly diagnosed
- soft tissue
- chronic kidney disease
- oxidative stress
- immune response
- prognostic factors
- peritoneal dialysis
- idiopathic pulmonary fibrosis