Novel Contrast-Enhanced Ultrasound Evaluation in Neonatal Hypoxic Ischemic Injury: Clinical Application and Future Directions.
Misun HwangRobert M De JongStephan HermanRenee BossBecky RiggsAylin Tekes-BradyMelissa SpevakAndrea PorettiBruno P SoaresChristopher R BaileyEmily DunnSamuel S ShinShai ShrotThierry A G M HuismanPublished in: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine (2017)
Sensitive, specific, and safe bedside evaluation of brain perfusion is key to the early diagnosis, treatment, and improved survival of neonates with hypoxic ischemic injury. Contrast-enhanced ultrasound (US) imaging is a novel imaging technique in which intravenously injected gas-filled microbubbles generate enhanced US echoes from an acoustic impedance mismatch. This article describes contrast-enhanced US imaging in 2 neonates with hypoxic ischemic injury and future directions on developing quantitative contrast-enhanced US techniques for improved characterization of perfusion abnormalities. The importance of studying the temporal evolution of brain perfusion in neonatal hypoxic ischemic injury is also highlighted.
Keyphrases
- contrast enhanced
- contrast enhanced ultrasound
- diffusion weighted
- magnetic resonance imaging
- magnetic resonance
- high resolution
- computed tomography
- diffusion weighted imaging
- resting state
- dual energy
- current status
- low birth weight
- functional connectivity
- multiple sclerosis
- cerebral ischemia
- mass spectrometry
- combination therapy
- preterm infants
- brain injury
- blood brain barrier
- smoking cessation
- fluorescence imaging