Enantiomeric NIR-II Emitting Rare-Earth-Doped Ag 2 Se Nanoparticles with Differentiated In Vivo Imaging Efficiencies.
Qi DingJing ZhaoHongyu ZhangChen LiMaozhong SunChen ChenHengwei LinChuanlai XuHua KuangLiguang XuPublished in: Angewandte Chemie (International ed. in English) (2022)
Here, chiral second near-infrared (NIR-II) emitting rare-earth doped silver selenide nanoparticles (R- or S-Ag 2 Se:Nd/Yd/Er NPs) were fabricated, exhibiting circular dichroism peak at 850 nm and fluorescence peak at 1550 nm, with 145.7-fold enhanced intensity compared to the reported Ag 2 Se NPs. Compared with S-Ag 2 Se:Nd/Yd/Er NPs, imaging efficiency of R-Ag 2 Se:Nd/Yd/Er NPs in living cells was significantly improved due to a higher cellular uptake rate and 927.7-fold higher affinity. Furthermore, R-Ag 2 Se:Nd/Yd/Er NPs reached at the tumor 2-fold faster than S type of NPs in vivo. We discover that chirality leads to differences in the affinity between chiral Ag 2 Se:Nd/Yd/Er NPs and cluster of differentiation 44 (CD44) onto the surface of murine mammary carcinoma cell to cause different in vivo imaging efficiency. These results reveal that chiral Ag 2 Se:Nd/Yd/Er NPs have high photoluminescence intensity and high in vivo imaging efficiency reflecting wide applications in biomedical diagnosis.
Keyphrases
- quantum dots
- highly efficient
- visible light
- high resolution
- fluorescent probe
- estrogen receptor
- endoplasmic reticulum
- oxide nanoparticles
- living cells
- energy transfer
- capillary electrophoresis
- breast cancer cells
- photodynamic therapy
- fluorescence imaging
- single molecule
- ionic liquid
- high intensity
- stem cells
- dna methylation
- mesenchymal stem cells
- mass spectrometry
- metal organic framework