Comparison of the pathogenicity and neutrophil and monocyte response between SARS-CoV-2 prototype and Omicron BA.1 in a lethal mouse model.

Na RongJing WuBinbin ZhaoWanjun PengHekai YangGengxin ZhangDangting RuanXiaohui WeiJiangning Liu

Published in: Animal models and experimental medicine (2024)

Our study provides valuable insights into the utility of mouse models for simulating the severe disease of SARS-CoV-2 prototype infection and the milder manifestation associated with Omicron BA.1. SARS-CoV-2 prototype and Omicron BA.1 resulted in similar trends in the changes in neutrophils and monocytes.

Keyphrases

sars cov
mouse model
respiratory syndrome coronavirus
dendritic cells
peripheral blood
endothelial cells
immune response
biofilm formation
cystic fibrosis
staphylococcus aureus
candida albicans