The anaesthetized rabbit with acute atrioventricular block provides a new model for detecting drug-induced Torsade de Pointes.

Mihoko HagiwaraSeiji ShibutaKazuhiro TakadaRyuichi KambayashiMisako NakajoMegumi AimotoYoshinobu NagasawaAkira Takahara

Published in: British journal of pharmacology (2017)

These results suggest that our model of the unremodelled and bradycardic heart of the anaesthetized rabbit is a useful test system for the detection of drug-induced TdP arrhythmias.

Keyphrases

drug induced
liver injury
adverse drug
heart failure
atrial fibrillation
hepatitis b virus
label free
real time pcr
acute respiratory distress syndrome